Nippon Chemical has developed a method for the industrial manufacture of the following chiral and achiral phosphine ligands by synthesizing alkyl phosphine compounds as building blocks.

Chiral ligand QuinoxP* is an orange-colored crystal with sufficient oxidation stability that can be handled readily by the customers.
Asymmetric hydrogenation reaction using QuinoxP enables synthesis of chiral α and β amino acids, as well as chiral amines, with high optical purity.

ItemChemical nameCAS NO.Structure
(R,R)-QuinoxP* (R,R)-2,3-Bis(tert-butylmethylphosphino)quinoxaline 866081-62-1 (R,R)-QuinoxP

Bisphosphine type ligands are suitable for CO insertion reaction and are typically used in aminocarbonylation in aromatic rings.

Item Chemical name CAS NO. Structure
DCyPP-FB 1,3-Bis(dicyclohexylphosphino)propane bis(tetrafluorobrate) 1002345-50-7 DCyPP-FB
DtBPP-FB 1,3-Bis(di-tert-butylphosphino)propane bis(tetrafluorobrate)
DCyPB-FB 1,4-Bis(dicyclohexylphosphino)butane bis(tetrafluorobrate)
DtBPB-FB 1,4-Bis(di-tert-butylphosphino)butane bis(tetrafluorobrate)

These phosphine ligands can be manufactured at kilogram levels on a pilot plant scale and higher. It is a fruit of technology (phosphine technology) that can only be achieved by our company, which manufactures all stages from ingredients (PH3) and intermediates (such as chlorodicyclohexylphosphine) to the final compound.

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